5 Plague-Related Video Games To Play

Most of the world remains locked down due to the coronavirus, even if some of our nations have started to open up our shops and restaurants again. Plague is something that a lot of us have never given any thought to before Covid-19 and it has been a frightening wake-up call about how vulnerable we are to disease. Indeed, some of us have lost friends and family to the disease.

Facing our fears is something that fantasy helps us deal with, though. Sometimes that’s in the form of electronic media like video games as well. As such, I am going to recommend five video games that deal with plague that you might feel like playing during this time of crisis. It isn’t for everyone and some would much prefer to play Animal Crossing or other games utterly removed from the subject. Those video games are not for me, though.

Tom Clancy’s The Division (Xbox One, Playstation 4, Microsoft Windows)

The Dollar Flu has ravaged the country and New York City in particular. As a member of a covert emergency response agency, you are given a pistol and a mission to execute whatever groups stand against the rebuilding of America. It’s a somewhat authoritarian narrative but the game is more aware of this than many people give it credit for as the Division turns out to not necessarily be the nicest bunch of people in the world. The best part of this game is the design of New York and the hundreds of short stories found on its collectables. Unfortunately, it’s designed for multiplayer and its fanbase has mostly moved on. As such, the game starts to get punishingly difficult by the end.

A Plague Tale: Innocence (Xbox One, Playstation 4, Microsoft Windows)

It’s the 13th century in Aquitaine France with the Hundred Years War in full swing. The Black Death descends upon the region like, well, a plague and you are left defending your poor brother from the Catholic Inquisition. The depiction of thousands of rats threatening to eat you and being a scared young woman hunted by armored soldiers is very well done. Amicia is a very likable character and while I wasn’t a big fan of her brother Hugo, I felt motivated to complete her quest. The game is an excellent mixture of stealth and puzzle-solving that gives you a sense of real power as you slowly learn how to ninja your way through the Inquisition’s ranks. Amicia will never battle armored men face-to-face but she’ll learn how to kill them like a Faceless Man trained Arya.

Vampyr (Xbox One, Playstation 4, Switch, Microsoft Windows)

Vampyr takes place in 1918 during the Spanish Flu. Jonathan Reid is a physician turned into a vampire when the outbreak is made worse by a horde of feral vampires. Most of the gameplay consists of a sort of easier Dark Souls-esque combat system where you fight hordes of the undead alongside vigilante vampire hunters. It is also added by a conversation system where Doctor Reid must determine which of the 60+ voiced NPCs will feed his immortal hunger. Doctor Reid is a bit of a wet blanket as protagonists go but the game’s atmosphere is top notch. I heartily recommend it for just the chance to whip up some potions to help the public if you can’t do it in real life.

Dishonored (Xbox One, Xbox 360, Playstation 3, Playstation 4, Microsoft Windows)

One of the best works of grimdark fantasy in gaming, Dishonored is the story of former Lord Protector Corvo Attano and his quest for revenge. Once the bodyguard and lover of Empress Emily, he fails Her Highness when she needs him most. Making a pact with the setting’s equivalent of Satan, he gains supernatural powers and goes on a killing spree through a plague-ridden steampunk kingdom. It is an amazing atmosphere, darkly evocative world, and Cthulhu-esque magic system. The game is also extremely good with its stealth mechanics and variety of oddball weapons. The only regret I have is that you’re not allowed to go on a monstrous killing spree unless you want the “Bad” ending.

The Last of Us (Playstation 4, Playstation 3)

Despite recent controversies over leaks, The Last of Us is often considered for the best storytelling by any game ever written. The story of the world being overrun by a fungal infection creates one of the most unique visions of a ‘zombie apocalypse’ you’re going to find. The characters of Joel and Ellie are the real reason to play this game, though, and are among the most beloved in a video game for a reason. The game itself is primarily a stealth one but includes enough action as well as set pieces to be really enjoyable. It’s a shame it’s only on one system.


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CT Phipps

CT Phipps

C.T Phipps is a lifelong student of horror, science fiction, and fantasy. An avid tabletop gamer, he discovered this passion led him to write and turned him into a lifelong geek. He's the author of Agent G, Cthulhu Armageddon, Lucifer's Star, Straight Outta Fangton, and The Supervillainy Saga. He is also a frequent contributor to Grimdark Magazine.